Scrape for Twitter locations (places that users can geo-tag Tweets to) from the Official Twitter API Places Search Endpoint. You can search by either latitude and longitude or use a free text search.
You probably want to use the coordinate search if you’re interested in finding popular locations in a given area and use the free text approach when searching for a specific location you already know the name of.
Once you have a list of places, you can then look up the Tweets that geo-tag that place using the Twitter API V2 search, but only if you have academic access approval. For whatever reason Twitter wants to prevent people from performing lookups by location unless you are part of an academic institution.